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MilliporeSigma™ anti-PTHLP (Ab-2) (34-53), Polyclonal

Rabbit Polyclonal Antibody

Manufacturer:  MilliporeSigma™ PC09100UG

Catalog No. PC09100UG

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Specifically detects PTHLP (34-53) Clone: in Human samples, and it is validated for Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Immuno Blotting

Parathyroid Hormone-Like Protein (PTHLP; also called Parathyroid Hormone-related Protein or PTHrP) is a polypeptide factor implicated in a severe neoplastic syndrome, Humoral Hypercalcemia of Malignancy, that is most commonly associated with renal cell and squamous cell carcinomas. It has been purified from tumors of patients with this syndrome and also from the conditioned medium of human tumor cell lines. Oligonucleotide probes, based upon the amino-terminal sequence of PTHLP, have been used to clone several cDNAs corresponding to alternatively spliced mRNAs that are both encoded by a single gene. Homogeneous recombinant PTHLP (141 amino acids) as well as synthetic peptides corresponding to the amino-terminal region of the protein havein vitro andin vivo biological activities as expected for a factor involved with calcium homeostasis. Immunohistochemical staining has shown PTHLP to be present in the keratinocyte layer of normal skin as well as in 34 out of 34 squamous or renal carcinomas but at a much lower percentage in adenocarcinomas.
Specifications

Specifications

PTHLP (34-53)
Unconjugated
purified
a synthetic peptide (AEIRATSEVSPNSKPSPNTK) corresponding to amino acids 34-53 of human PTHLP
100μg
2°C to 8°C
Polyclonal
Human
Flow Cytometry, Immuno Blotting, Immunoblot, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
In 0.05M sodium phosphate buffer, 0.2% gelatin.
Rabbit
IgG
RUO
Primary
Recognizes parathyroid hormone-like protein. Does not cross-react with human PTH.
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