MilliporeSigma anti-PTHLP (Ab-2) (34-53), Polyclonal
Rabbit Polyclonal Antibody
Manufacturer: MilliporeSigma PC09100UG
Specifically detects PTHLP (34-53) Clone: in Human samples, and it is validated for Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Immuno BlottingParathyroid Hormone-Like Protein (PTHLP; also called Parathyroid Hormone-related Protein or PTHrP) is a polypeptide factor implicated in a severe neoplastic syndrome, Humoral Hypercalcemia of Malignancy, that is most commonly associated with renal cell and squamous cell carcinomas. It has been purified from tumors of patients with this syndrome and also from the conditioned medium of human tumor cell lines. Oligonucleotide probes, based upon the amino-terminal sequence of PTHLP, have been used to clone several cDNAs corresponding to alternatively spliced mRNAs that are both encoded by a single gene. Homogeneous recombinant PTHLP (141 amino acids) as well as synthetic peptides corresponding to the amino-terminal region of the protein havein vitro andin vivo biological activities as expected for a factor involved with calcium homeostasis. Immunohistochemical staining has shown PTHLP to be present in the keratinocyte layer of normal skin as well as in 34 out of 34 squamous or renal carcinomas but at a much lower percentage in adenocarcinomas.
|a synthetic peptide (AEIRATSEVSPNSKPSPNTK) corresponding to amino acids 34-53 of human PTHLP|
|2°C to 8°C|
|Flow Cytometry, Immuno Blotting, Immunoblot, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation|
|In 0.05M sodium phosphate buffer, 0.2% gelatin.|
|Recognizes parathyroid hormone-like protein. Does not cross-react with human PTH.|
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