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PUMA alpha Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141157

Catalog No. 01-675-734


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Description

Description

Suggested positive control: NIH-3T3 or Jurkat whole cell lysate.

PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.
Specifications

Specifications

PUMA alpha
Polyclonal
Unconjugated
BBC3
Liquid
BBC3
Synthetic peptide corresponding to the C-terminal residues of human PUMAA.
Protein G
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
Q96PG8, Q99ML1
FLJ42994, JFY1, PUMA
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
170770, 27113
Documents
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