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PKLR Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527305

Catalog No. PIPA527305


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Description

Description

PA5-27305 targets Pyruvate Kinase (liver/RBC) in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-27305 immunogen is recombit fragment corresponding to a region within amino acids 178 and 550 of Human Pyruvate Kinase. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

PKLR
Polyclonal
Unconjugated
PKLR
Liquid
PKLR
Recombit fragment corresponding to a region within amino acids 178 and 550 of Human Pyruvate Kinase
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Rat
Immunohistochemistry (Paraffin), Western Blot
1.01 mg/mL
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
P30613, P12928
PK1, PKL, PKR, PKRL, RPK, R-type/L-type pyruvate kinase, pyruvate kinase 1, pyruvate kinase isozyme R/L, pyruvate kinase isozymes R/L, pyruvate kinase type L, pyruvate kinase, liver and blood cell, red cell/liver pyruvate kinase
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
24651, 5313
Documents
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