RAB3c Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1772
PA1-772 detects rab 3C from mouse and rat tissues and cells. PA1-772 has been successfully used in Western blot and immunoprecipitation procedures. By Western blot, this antibody detects a 22 kDa protein representing rab 3C from AtT20 cell extract. PA1-772 immunogen is a synthetic peptide corresponding to residues M(9) A S A Q D A R F G Q K D S S D Q N(26) C of rat RAB3C. This immunizing peptide (Cat. No. PEP-106) is available for use in neutralization and control experiments.Rab proteins are low-molecular-weight GTP-binding proteins that form the largest branch of the Ras superfamily of GTPases. Located on the cytoplasmic face of organelles and vesicles, rab proteins are involved in intracellular membrane fusion reactions. Three membrane proteins, synaptosomal associated protein of 25 kDa (SNAP-25), synaptobrevin, and syntaxin, form the core of a ubiquitous membrane fusion machine that interacts with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and a-SNAP. Rab proteins, in coordination with the core fusion machinery and Munc-18, help to mediate vesicle docking and fusion. There exist over 40 Rab proteins that have been described in mammals. Rab 3C is found in brain, adrenal gland, and pituitary.
|Synthetic peptide corresponding to residues M(9) A S A Q D A R F G Q K D S S D Q N(26) C of rat RAB3C.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunoprecipitation, Western Blot|
|PBS with 1mg/mL BSA and 0.05% sodium azide|
|Q96E17, P62823, P62824|
|Ras-Associated Protein 3C|
|-20° C, Avoid Freeze/Thaw Cycles|
|115827, 171058, 67295|
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