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Rab8 Mouse, Unlabeled, Clone: 4, BD

Mouse Monoclonal Antibody

$232.00 - $458.00

Specifications

Antigen Rab8
Isotype IgG2b
Immunogen Human Rab8 aa. 84-205
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610845
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BD Biosciences
610845
150μg
Each for $458.00
Add to cart
 
BDB610844
View Documents
BD Biosciences
610844
50μg
Each for $232.00
Add to cart
 
Description

Description

The members of the Ras superfamily of GTPases, which now includes more than 50 different proteins, shuttle between the GDP-bound inactive position and the GTP-bound active state. The GTPase activity of the Ras-like proteins is regulated by effectors that promote either the GDP- or the GTP-bound states. GTPases of the Ras superfamily have a role in controlling numerous events such as cell proliferation, nucleocytoplasmic transport, and vesicular traffic. The Rab superfamily of proteins includes more than 30 different members that are involved in the regulation of different steps of vesicular traffic. Subcellular localization and specific cellular function of each Rab appears to be encoded in the unique C terminal part of the proteins, known as the hypervariable region. The 207 amino acid Rab8 protein is closely related to the yeast Sec4p and regulates vesicle transport from the Trans-golgi Network to the basolateral plasma membrane in epithelial cells. In addition, Rab8 interacts with the stress-activated kinase rab8p, a close homologue of the GC Kinase. This interaction was found to be dependent on GTP.

Immunofluorescence, Immunoprecipitation, Western Blotting

Specifications

Specifications

Rab8
Human Rab8 aa. 84-205
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG2b
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
4
250μg/mL
SDS
Product Certifications

For Research Use Only.

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