MilliporeSigma™ anti-Rac1 Alexa Fluor 488, Clone: 23A8,
Mouse Monoclonal Antibody
Manufacturer: MilliporeSigma™ 05389AF488
Specifically detects Rac1 Clone: 23A8 in Human, Mouse, Rat samples, and it is validated for ImmunocytochemistryRas-related C3 botulinum toxin substrate 1 (UniProt P63000; also known as Cell migration-inducing gene 5 protein, p21-Rac1, Rac-1, Ras-like protein TC25, TC-25) is encoded by the RAC1 (also known as TC25) gene (ORF MIG5; Gene ID 5879) in human. Rac1, RhoA, and Cdc42 (UniProt P63000, P61586, and P60953, respectively) are among the most studied Rho family of small GTPases that are involved in a wide variety of cellular functions, including cell polarity, vesicular trafficking, and cell cycle by regulating intracellular actin dynamics. In mammals, the Rho family consists of 22 members, which can be further divided into the Rac subfamily (Rac1, Rac2, Rac3, and RhoG), Cdc42 subfamily (Cdc42, TC10, TCL, Chip, and Wrch-1), RhoA subfamily (RhoA, RhoB, and RhoC) and other Rho-GTPases (RhoE/Rnd3, RhoH/TTF, Rif, RhoBTB1, RhoBTB2, Miro-1, Miro-2, RhoD, Rnd1, and Rnd2). Akt is reported to negatively regulate mixed-lineage kinase 3 (MLK3) by phosphorylating Rac1 at Ser71.
|Purified mouse antibody conjugate in PBS with 15mg/mL BSA and 0.1% sodium azide.|
|Human, Murine, Rat|
|Alexa Fluor 488|
|RAC1, TC25, MIG5|
|Recombinant protein containing the full length human Rac.|
|Protein G purified|
|2°C to 8°C for one year from date of shipment|
|Recognizes Rac1; Strong Rac1 preference with slight Rac2 cross-reactivity.|
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