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MilliporeSigma™ anti-Rac1 Alexa Fluor 488, Clone: 23A8,

Mouse Monoclonal Antibody

Manufacturer:  MilliporeSigma™ 05389AF488

Catalog No. 05-389-AF488


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Description

Description

Specifically detects Rac1 Clone: 23A8 in Human, Mouse, Rat samples, and it is validated for Immunocytochemistry

Ras-related C3 botulinum toxin substrate 1 (UniProt P63000; also known as Cell migration-inducing gene 5 protein, p21-Rac1, Rac-1, Ras-like protein TC25, TC-25) is encoded by the RAC1 (also known as TC25) gene (ORF MIG5; Gene ID 5879) in human. Rac1, RhoA, and Cdc42 (UniProt P63000, P61586, and P60953, respectively) are among the most studied Rho family of small GTPases that are involved in a wide variety of cellular functions, including cell polarity, vesicular trafficking, and cell cycle by regulating intracellular actin dynamics. In mammals, the Rho family consists of 22 members, which can be further divided into the Rac subfamily (Rac1, Rac2, Rac3, and RhoG), Cdc42 subfamily (Cdc42, TC10, TCL, Chip, and Wrch-1), RhoA subfamily (RhoA, RhoB, and RhoC) and other Rho-GTPases (RhoE/Rnd3, RhoH/TTF, Rif, RhoBTB1, RhoBTB2, Miro-1, Miro-2, RhoD, Rnd1, and Rnd2). Akt is reported to negatively regulate mixed-lineage kinase 3 (MLK3) by phosphorylating Rac1 at Ser71.
Specifications

Specifications

Rac1
23A8
Purified mouse antibody conjugate in PBS with 15mg/mL BSA and 0.1% sodium azide.
Purified
Murine
IgG2b
100μL
Signaling
Primary
NM_006908
Human, Murine, Rat
Immunocytochemistry
Alexa Fluor 488
P63000
RAC1, TC25, MIG5
Recombinant protein containing the full length human Rac.
Protein G purified
RUO
2°C to 8°C for one year from date of shipment
Monoclonal
Recognizes Rac1; Strong Rac1 preference with slight Rac2 cross-reactivity.
SDS
Documents
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