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Phospho-RAD17 (Ser647) Rabbit anti-Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141545

Catalog No. 01-675-365


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Description

Description

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.
Specifications

Specifications

Phospho-RAD17 (Ser647)
Polyclonal
Unconjugated
Rad17
Liquid
RAD17
Synthetic phosphopeptide corresponding to residues 644-652 L(644) P L S(p) Q N S G S(652) of mouse Rad17.
Protein G
RUO
Antibody
Polyclonal
Mouse
Western Blot
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
Q6NXW6
RAD17 (Ser647)
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
19356
Documents
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