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RAD18 Mouse anti-Human, Clone: 79B1048.1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141077

Catalog No. 01-676-462


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Description

Description

Human Rad18 (hRad18) is homologue of the S. pombe Rad18 (3,4). In yeast, Rad6 and Rad18 play a crucial role in post-replication repair functions in gap-filling of a daughter strand on replication of damaged DNA (2). Furthermore, Rad6-Rad18 interaction is thought to be critical at an early step during lesion bypass in yeast. In vivo, Rad18 protein forms a tight complex with Rad6 through a conserved ring-finger motif (3,4). It has been suggested that Rad18-Rad6 complex binds to the damaged sites by the single-stranded DNA binding property of Rad 18. This is followed by degradation of the stalled components of DNA replication by ubiquitin-conjugating enzyme activity of Rad6 (1). The human Rad18 maps on chromosome 3p24-25, the region which is often deleted in lung, breast, ovary, and testis cancers. The human RAD18 gene codes for a protein of 495 amino acids with a predicted molecular weight of 56 kDa. The human Rad18 is ubiquitously expressed in various human tissues.

Suggested positive control: HL-60, antigen standard for RAD18 (transient overexpression lysate).
Specifications

Specifications

RAD18
Monoclonal
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
Q9NS91
RNF73
Mouse
IgG1
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
56852
Western Blot
79B1048.1
Unconjugated
RAD18
Liquid
RAD18
Synthetic peptide corresponding to residues 402-414 of human Rad18.
Protein G
RUO
Antibody
Monoclonal
Human
Documents
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