Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

RAGE Rabbit anti-Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1075

Catalog No. PA1075


Add to cart

Description

Description

PA1-075 detects receptor for advanced glycation endproducts (RAGE) from mouse and rat samples. PA1-075 has been successfully used in Western blot and immunohistochemistry procedures. By Western blot, this antibody detects two bands in the 45 kDa range representing the RAGE protein pre and post-glycosylation in mouse lung extract. This antibody also detects an ~25 kDa protein that is believed to be proteolytic degradation product. Immunohistochemical staining of RAGE in transgenic mouse retina results in staining of the retinal pigmented epithelium and photo receptor cell layers. The PA1-075 immunogen is a synthetic peptides corresponding to residues C(362) W R K R Q P R (R/L) E E R K A P E S Q E D(380) of rat RAGE. This sequence is 100% conserved in mouse and 70% conserved in humans. This peptide (Cat. No. PEP-194) is available for use in neutralization and control experiments.

The receptor for advanced glycation endproducts (RAGE) is a member of the Immunoglobin superfamily of cell surface markers. This protein is able to interact with many molecules including: advanced glycation endproducts (AGE), amphoterin, and ligands. Research has shown that the accumulation of RAGE ligands in the biological system (endothelium mononuclear phagocytes, neurons and smooth muscle cells) can lead to destructive tissue diseases such as diabetic retinopathy, amyloidoses, tumors and inflammation disorders.
Specifications

Specifications

RAGE
Polyclonal
Unconjugated
Ager
Liquid
AGER
Synthetic peptides corresponding to residues C(362) W R K R Q P R (R/L) E E R K A P E S Q E D(380) of rat RAGE.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Mouse, Rat
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
Q62151, Q63495
Receptor for Advanced Glycation End Products, Soluble form of receptor for advanced glycation endproducts, Receptor for advanced glycosylation end-pro
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
11596, 81722
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit