RAIDD Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA519865
In Western blot applications, this antibody detects a band at ~22kDa. A suggested positive control is Hela cell lysate.Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain (DD)-containing receptors, TNFR1 and Fas. The death signals are transduced by a group of DD-containing adapter molecules. A novel cell death adapter was recently identified by two independent groups and designated RAIDD (RIP-associated ICH-1/CED-3-homologous protein with DD) and CRADD (caspase and RIP adapter with DD)1, RAIDD contains a DD and a CARD (for caspase recruitment domain) which interact with RIP and caspase, respectively, to transduce death signals. RAIDD is constitutively expressed in many tissues and mediates apoptosis caused by Fas and TNFR-1.
|PBS with 0.02% sodium azide|
|RAIDD; RIP-associated ICH1/CED3-homologous protein with death domain; RIP-associated protein with a death domain; caspase and RIP adapter with death domain; caspase and RIP adaptor with death domain; death adaptor molecule RAIDD; death domain containing protein CRADD; death domain-containing protein CRADD|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Immunohistochemistry, Western Blot|
|A peptide corresponding to amino acids near the carboxy terminus of human RAIDD.|
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