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RanBP1 Mouse anti-Human, Unlabeled, Clone: 35, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610756

Catalog No. BDB610756


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Description

Description

Ran is a highly conserved GTPase that is ubiquitously expressed. Ran has been implicated in a number of cellular processes such as the initiation of DNA replication, entry into and exit from mitosis, and in nuclear RNA and protein transport through the nuclear pore complex. A number of Ran binding proteins have been identified. One of the smaller proteins identified is a 29kDa cytosolic molecule known as RanBP1. The GTP-bound state of Ran is stabilized through its binding to RanBP1. In addition, RanBP1 appears to regulate the activity of Ran-GAP1 (Ran-GTPase activating protein) by increasing GTP hydrolysis. RanBP1 also inhibits the function of the guanine nucleotide exchange factor RCC1 (regulator of chromosome condensation). Therefore, RanBP1 is responsible for the GTP-bound state of Ran and the increased GTP hydrolysis of Ran GTP.

Immunofluorescence, Western Blotting

Specifications

Specifications

RanBP1
35
Unconjugated
Affinity Purified
Human RanBP1 aa. 28-163
50μg
Cell Biology
Primary
Human
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG2a
RUO
Store undiluted at -20°C.
Monoclonal
SDS
Documents
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