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RANGAP1 Rabbit anti-Human, Xenopus laevis, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA15866

Catalog No. 01-675-402


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Description

Description

Ran is a small signaling GTPase that is involved in nucleocytoplasmic transport. Two additional functions of animal Ran in the formation of spindle asters and the reassembly of the nuclear envelope in mitotic cells have been recently reported. In contrast to Ras or Rho, Ran is not associated with membranes. Instead, the spatial sequestering of its accessory proteins, the Ran GTPase-activating protein RanGAP and the nucleotide exchange factor RCC1, appears to define the local concentration of RanGTP vs. RanGDP involved in signaling. Mammalian RanGAP is bound to the nuclear pore by a mechanism involving the attachment of small ubiquitin-related modifier protein (SUMO) to its C terminus and the subsequent binding of the SUMOylated domain to the nucleoporin Nup358.

PA1-5866 detects RanGAP in human and xenopus samples.PA1-5866 has been successfully used in immunofluorescence, immunohistochemistry (paraffin) and Western blot procedures.The PA1-5866 immunogen is two peptides: n-CHWSDMFTGRLRPEI-c & n-CPSPEKLVRMGPRRSA-c, from Xenopus RanGAP.
Specifications

Specifications

RANGAP1
Polyclonal
whole serum diluted in PBS with 0.1% sodium azide
P46060, O13066
Fug1, KIAA1835, MGC20266, SD
Rabbit
IgG
RUO
Antibody
Polyclonal
Human, Xenopus laevis
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
RANGAP1
Liquid
RANGAP1, rangap1.L, rangap1.S
A mixture of two peptides from Xenopus RanGAP, n-CHWSDMFTGRLRPEI-c n-CPSPEKLVRMGPRRSA-
100 μL
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Primary
100337588, 379922, 5905
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