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RANGAP1 Goat anti-Human, Mouse, Polyclonal, Invitrogen™

Goat Polyclonal Antibody

Manufacturer:  Invitrogen PA19094

Catalog No. 01-674-676


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Description

Description

This antibody is predicted to react with bovine, canine and rat based on sequence homology.

RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1, 000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.
Specifications

Specifications

RANGAP1
Polyclonal
Unconjugated
RANGAP1
Liquid
RANGAP1
Synthetic peptide corresponding to the N terminus amino acids ASEDIAKLAETLAK.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry, Immunohistochemistry (Paraffin), peptide-ELISA, Western Blot
0.5 mg/mL
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
P46060, P46061
RANGAP1; KIAA1835; Ran GTPase activating protein 1; Fug1
Goat
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
19387, 5905
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