RANGAP1 Goat anti-Human, Mouse, Polyclonal, Invitrogen™
Goat Polyclonal Antibody
Manufacturer: Invitrogen PA19094
This antibody is predicted to react with bovine, canine and rat based on sequence homology.RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1, 000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.
|Synthetic peptide corresponding to the N terminus amino acids ASEDIAKLAETLAK.|
|Antigen affinity chromatography|
|Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot|
|TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3|
|RANGAP1; KIAA1835; Ran GTPase activating protein 1; Fug1|
|-20° C, Avoid Freeze/Thaw Cycles|
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