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RANGAP1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA528420

Catalog No. PIPA528420


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Description

Description

PA5-28420 targets RanGAP1 in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-28420 immunogen is synthetic peptide corresponding to a region within amino acids 1 and 45 of Human RanGAP1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.
Specifications

Specifications

RanGAP1
Polyclonal
Unconjugated
RANGAP1
Liquid
RANGAP1
Synthetic peptide corresponding to a region within amino acids 1 and 45 of Human RanGAP1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 10% glycerol and 0.01% thimerosal; pH 7
P46060
Fug1, SD, ran GTPase-activating protein 1, segregation distorter homolog, segregation distortion
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
5905
Documents
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