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RANK Mouse anti-Human, Mouse, Clone: 64C1385.1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141048

Catalog No. 01-676-454


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Description

Description

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Receptor activator of NF-kB (RANK) is a recently cloned member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand (RANKL/TRANCE/ OPGL) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-kB and c-Jun-terminal kinase (JNK) pathways. Recent studies have shown that RANK interaction with TRAF6 activates NF-kB, whereas JNK activation is mediated through binding of RANK to TRAF2.
Specifications

Specifications

RANK
Monoclonal
1.0 mg/mL
PBS with 0.05% sodium azide
Q9Y6Q6, O35305
FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCER, TNFRSF11A
Mouse
IgG1, lambda
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
21934, 8792
Flow Cytometry, Immunoprecipitation, Western Blot
64C1385.1
Unconjugated
TNFRSF11A
Liquid
TNFRSF11A
Recombit protein corresponding to the extracellular domain (aa 33-208) of human RANK.
Protein G
RUO
Antibody
Monoclonal
Human, Mouse
Documents
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