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CD254 (RANK Ligand) Mouse anti-Human, Mouse, Clone: 12A380, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141019

Catalog No. 01-676-437


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Description

Description

Suggested positive control: activated T cells or RAW cells, antigen standard for TNFSF11 (transient overexpression lysate).

TRANCE/OPGL/RANKL/ODF is a recently identified member of tumor necrosis factor family. TRANCE (TNF-related activation-induced cytokine receptor) or RANKL {receptor activator of NF-kB (RANK) ligand} has been implicated in interactions between T cells and dendritic cells (4-5). RANK ligand (RANKL/TRANCE) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival (4). TRANCE/RANKL is also important in T- and B-cell maturation (3). As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis (1,2). OPGL/TRANCE deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis (3).
Specifications

Specifications

CD254 (RANK Ligand)
Monoclonal
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
O14788, O35235
RP11-86N24.2, CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf, TNF-related activation-induced cytokine, TNFSF11, TRANCE
Mouse
IgG1, kappa
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
21943, 8600
Flow Cytometry, Immunohistochemistry (Frozen), Western Blot
12A380
Unconjugated
TNFSF11
Liquid
TNFSF11
Bacterially expressed fusion protein containing residues 1-317 of mouse RANK ligand.
Protein G
RUO
Antibody
Monoclonal
Human, Mouse
Documents
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