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CD254 (RANK Ligand) Rabbit anti-Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141318

Catalog No. 01-675-655


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Description

Description

TRANCE/OPGL/RANKL/ODF is a recently identified member of tumor necrosis factor family. TRANCE (TNF-related activation-induced cytokine receptor) or RANKL {receptor activator of NF-kB (RANK) ligand} has been implicated in interactions between T cells and dendritic cells (1-2). RANK ligand (RANKL/TRANCE) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival (2). TRANCE/RANKL is also important in T- and B-cell maturation (3). As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis (4,5). OPGL/TRANCE deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis (3). Mouse Trance/RANKL is a 316 amino acid protein.
Specifications

Specifications

CD254 (RANK Ligand)
Polyclonal
Unconjugated
Tnfsf11
Liquid
TNFSF11
Synthetic peptide corresponding to residues A(161) Q P F A H L T I N A A S I P S G(177) of mouse RANK-L.
Protein G
RUO
Antibody
Polyclonal
Mouse, Rat
Western Blot
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
O35235, Q9ESE2
RP11-86N24.2, CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf, TNF-related activation-induced cytokine, TNFSF11, TRANCE
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
117516, 21943
Documents
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