Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

RANK Mouse anti-Human, Mouse, Rat, PE, Clone: 9A725, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141015

Catalog No. 01-676-435


Add to cart

Description

Description

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Receptor activator of NF-kB (RANK) is a recently cloned member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand  (RANKL/TRANCE/ OPGL) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-kB and c-Jun-terminal kinase (JNK) pathways. Recent studies have shown that RANK interaction with TRAF6 activates NF-kB, whereas JNK activation is mediated through binding of RANK to TRAF2 .

This antibody recognizes an epitope located between amino acid residues 330-427 of human RaNK.Suggested positive control: Raw.
Specifications

Specifications

RANK
Monoclonal
0.29 mg/mL
PBS with 0.05% sodium azide
Q9Y6Q6, O35305
FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCER, TNFRSF11A
Mouse
IgG1, kappa
100 μL
4° C, store in dark
Primary
21934, 498206, 8792
Flow Cytometry
9A725
PE
TNFRSF11A
Liquid
TNFRSF11A
Fusion protein containing residues 326-616 of human RANK.
Protein G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit