Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

RAP1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141267

Catalog No. 01-675-613


Add to cart

Description

Description

Human Rap1 was the first identified ortholog of the yeast telomeric protein scRap1, which shares 3 conserved sequence motifs in common. HRap1 is located at telomeres and affects telomere length by being recruited to telomeres by TRF2 instead of directly binding to the telomere like scRap1. The hRap1 cDNA codes for a protein of 399 amino acids with approximate molecular weight of 47 kDa. The hRap1 protein does not interact with TRF1. TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length(1). TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes (5). TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini (4). The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells (4). Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types (3).

Suggested positive control: 293 whole cell lysate, antigen standard for TERF2IP (transient overexpression lysate).
Specifications

Specifications

RAP1
Polyclonal
Unconjugated
TERF2IP
Liquid
TERF2IP
Synthetic peptide corresponding to residues 212-235 of human Rap1.
Protein G
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
1.0 mg/mL
PBS with 0.02% sodium azide
Q9NYB0, Q91VL8
TERF2IP; TERF21P; telomeric repeat binding factor 2, interacting protein; DRIP5; RAP1; TRF2-interacting telomeric RAP1 protein; dopamine receptor interacting protein 5; hRAP1
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
54386, 57321
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit