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RAP80 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520414

Catalog No. PIPA520414


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Description

Description

A suggested positive control is 293 cell lysate. PA5-20414 can be used with blocking peptide PEP-0531.

RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1. At least four isoforms of RAP80 are known to exist.
Specifications

Specifications

RAP80
Polyclonal
Unconjugated
UIMC1
Liquid
UIMC1
A 17 amino acid peptide from near the amino terminus of human RAP80.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q96RL1, Q5U5Q9
RAP80, X2HRIP110; BRCA1-A complex subunit RAP80; receptor associated protein 80; receptor-associated protein 80; retinoid X receptor-interacting protein 110; retinoid x receptor interacting protein; ubiquitin interaction motif-containing protein 1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
20184, 51720
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