RASGRP3 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA528091
PA5-28091 targets RASGRP3 in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-28091 immunogen is synthetic peptide corresponding to a region within amino acids 1 and 44 of Human RASGRP3. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).
|Synthetic peptide corresponding to a region within amino acids 1 and 44 of Human RASGRP3|
|Antigen affinity chromatography|
|Immunohistochemistry (Paraffin), Western Blot|
|0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7|
|GRP3, calcium and DAG-regulated guanine nucleotide exchange factor III, guanine nucleotide exchange factor for Rap1, ras guanyl-releasing protein 3|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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