CD1d Mouse anti-Rat, PE, Clone: WTH1 (also known as WTH-1), BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 564632
The WTH1 monoclonal antibody specifically binds to rat CD1d and crossreacts with mouse CD1d (with stronger reactivity against mouse CD1d1 than CD1d2). CD1d is a type I transmembrane glycoprotein that is noncovalently associated with β2-microglobulin. CD1d is expressed on various cell types including subsets of thymocytes, T cells, B cells, monocytes, macrophages, dendritic cells, endothelial cells and epithelial cells. Although structurally similar to MHC Class I antigens, CD1d molecules are rather non-polymorphic and serve to present non-peptide antigens such as endogenous or microbial glycolipids to T lymphocytes (NKT cells). The WTH2 monoclonal antibody reportedly binds to a non-overlapping epitope on rat CD1d and also crossreacts with mouse CD1d when compared with WTH1. Both WTH1 and WTH2 reportedly interfere with antigen recognition by CD1d-restricted T cells.
|WTH1 (also known as WTH-1)|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Cd1d; Cd1d1; Antigen-presenting glycoprotein CD1d|
|Rat CD1d Transfected Cell Line|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
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