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anti-P2X7/P2RX7, Alexa Fluor 700, Clone: Hano43, Novus Biologicals™

Rat Monoclonal Antibody

Manufacturer:  Novus Biologicals NBP140894AF700

Catalog No. NBP140894Z


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Description

Description

P2X7/P2RX7 Monoclonal antibody specifically detects P2X7/P2RX7 in Mouse samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence.
Specifications

Specifications

P2X7/P2RX7
Hano43
Flow Cytometry, Immunocytochemistry/Immunofluorescence
Purified
P2RX7
A P2X7-expression construct and a final boost with P2X7-transfected HEK cells.
Protein G purified
RUO
Primary
5027
Mouse
Flow Cytometry, Immunocytochemistry, Immunofluorescence
Alexa Fluor 700
50mM Sodium Borate with 0.05% Sodium Azide
ATP receptor, MGC20089, P2X purinoceptor 7, P2X7P2X7 receptor, P2X7R, P2Z receptor, Purinergic receptor, purinergic receptor P2X, ligand-gated ion channel, 7, purinergic receptor P2X7 variant A
Rat
IgG2b
0.1 ml
Store at 4C in the dark.
Monoclonal
This antibody recognises the P2X purinoceptor 7, also known as P2X7. The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic. It is a cation selective ion channel that opens up on binding of extracellular ATP. Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da. Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP. Should ATP stimulation continue the cell will become irreversibly damaged and die. P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation. As such, P2X7 blockers might be useful as anti-inflammatory agents.
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