Rb Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527215
PA5-27215 targets Rb in WB applications and shows reactivity with Human samples. The PA5-27215 immunogen is recombit protein fragment corresponding to a region within amino acids 727 and 897 of Human Rb. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
|Recombit protein fragment corresponding to a region within amino acids 727 and 897 of Human Rb|
|Antigen affinity chromatography|
|Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|PBS with 20% glycerol and 0.025% ProClin 300; pH 7|
|OSRC, RB, p105-Rb, pRb, pp110, retinoblastoma suspectibility protein, retinoblastoma-associated protein|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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