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Rb Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527215

Catalog No. PIPA527215


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Description

Description

PA5-27215 targets Rb in WB applications and shows reactivity with Human samples. The PA5-27215 immunogen is recombit protein fragment corresponding to a region within amino acids 727 and 897 of Human Rb. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Specifications

Specifications

Rb
Polyclonal
Unconjugated
RB1
Liquid
RB1
Recombit protein fragment corresponding to a region within amino acids 727 and 897 of Human Rb
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
0.56 mg/mL
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
P06400
OSRC, RB, p105-Rb, pRb, pp110, retinoblastoma suspectibility protein, retinoblastoma-associated protein
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
5925
Documents
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