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RbAp46 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1868

Catalog No. PA1868


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Description

Description

PA1-868 detects retinoblastoma protein (Rb) associated protein 46 (RbAp46) from human cells. PA1-868 has been successfully used in IF, Western blot and immunocytochemical procedures. By Western blot, this antibody detects an ~46 kDa protein representing RbAp46 from HeLa cell lysate. Immunocytochemical staining of RbAp46 in HeLa cells with PA1-868 results in nuclear staining. The PA1-868 immunogen is a synthetic peptide corresponding to residues M(1) A S K E M F E D T V E E(13) C of human RbAp46. This sequence is completely conserved between human and mouse. This immunizing peptide (Cat. No. PEP-083) is available for use in neutralization and control experiments.

Retinoblastoma protein (Rb) associated protein 46 (RbAp46) is a nuclear protein that has been shown to interact directly with retinoblastoma protein and is a component of the mSin3 corepressor complex as are the histone deacetylase proteins (HDACs). RbAp46 shares about 75% sequence identity with the closely related RbAp48, and appears to be functionally related to the yeast MSI1 protein in that overexpression of RbAp46 suppresses heat shock sensitivity in a RAS pathway dependent manner. RbAp46 has also been demonstrated to be up-regulated by the Wilms’ tumor suppressor gene product, WT1. Additionally, cells transfected with RbAp46 have shown strong inhibition of growth.
Specifications

Specifications

RbAp46
Polyclonal
Unconjugated
RBBP7
Liquid
RBBP7
Synthetic peptide corresponding to residues M(1) A S K E M F E D T V E E(13) C of human RbAp46.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
Q16576
Retinoblastoma Associated Protein 48
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
5931
Documents
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