RbAp46 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1868
PA1-868 detects retinoblastoma protein (Rb) associated protein 46 (RbAp46) from human cells. PA1-868 has been successfully used in IF, Western blot and immunocytochemical procedures. By Western blot, this antibody detects an ~46 kDa protein representing RbAp46 from HeLa cell lysate. Immunocytochemical staining of RbAp46 in HeLa cells with PA1-868 results in nuclear staining. The PA1-868 immunogen is a synthetic peptide corresponding to residues M(1) A S K E M F E D T V E E(13) C of human RbAp46. This sequence is completely conserved between human and mouse. This immunizing peptide (Cat. No. PEP-083) is available for use in neutralization and control experiments.Retinoblastoma protein (Rb) associated protein 46 (RbAp46) is a nuclear protein that has been shown to interact directly with retinoblastoma protein and is a component of the mSin3 corepressor complex as are the histone deacetylase proteins (HDACs). RbAp46 shares about 75% sequence identity with the closely related RbAp48, and appears to be functionally related to the yeast MSI1 protein in that overexpression of RbAp46 suppresses heat shock sensitivity in a RAS pathway dependent manner. RbAp46 has also been demonstrated to be up-regulated by the Wilms’ tumor suppressor gene product, WT1. Additionally, cells transfected with RbAp46 have shown strong inhibition of growth.
|Synthetic peptide corresponding to residues M(1) A S K E M F E D T V E E(13) C of human RbAp46.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 1mg/mL BSA and 0.05% sodium azide|
|Retinoblastoma Associated Protein 48|
|-20° C, Avoid Freeze/Thaw Cycles|
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