RbAp48 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1869
Retinoblastoma protein (Rb) associated protein 48 (RbAp48) is a nuclear protein that has been shown to interact directly with retinoblastoma protein and is a component of the mSin3 corepressor complex as are the histone deacetylase proteins (HDACs). RbAp48 shares about 75% sequence identity with the closely related RbAp46, and appears to be functionally related to the yeast MSI1 protein in that overexpression of RbAp48 suppresses heat shock sensitivity in a RAS pathway dependent manner. RbAp48 has also been demonstrated to be up-regulated by the Wilms’ tumor suppressor gene product, WT1. Additionally, cells transfected with RbAp48 have shown strong inhibition of growth.PA1-869 detects retinoblastoma protein (Rb) associated protein 48 (RbAp48) from human cells.PA1-869 has been successfully used in IF and Western blot procedures. By Western blot, this antibody detects an ~48kDa protein representing RbAp48 and a larger ~60kDa unknown protein from HeLa cell lysate.The PA1-869 immunogen is a synthetic peptide corresponding to residues M(1) A D K F A A F D D A V E E(14) C of human RbAp48. This sequence is completely conserved between human and mouse RbAp48. This immunizing peptide (Cat. # PEP-084) is available for use in neutralization and control experiments.
|Synthetic peptide corresponding to residues M(1) A D K F A A F D D A V E E(14) C of human RbAp48.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 1mg/mL BSA and 0.05% sodium azide|
|Retinoblastoma Associated Protein 48|
|-20° C, Avoid Freeze/Thaw Cycles|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok