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RbAp48 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1869

Catalog No. PA1869

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Retinoblastoma protein (Rb) associated protein 48 (RbAp48) is a nuclear protein that has been shown to interact directly with retinoblastoma protein and is a component of the mSin3 corepressor complex as are the histone deacetylase proteins (HDACs). RbAp48 shares about 75% sequence identity with the closely related RbAp46, and appears to be functionally related to the yeast MSI1 protein in that overexpression of RbAp48 suppresses heat shock sensitivity in a RAS pathway dependent manner. RbAp48 has also been demonstrated to be up-regulated by the Wilms’ tumor suppressor gene product, WT1. Additionally, cells transfected with RbAp48 have shown strong inhibition of growth.

PA1-869 detects retinoblastoma protein (Rb) associated protein 48 (RbAp48) from human cells.PA1-869 has been successfully used in IF and Western blot procedures. By Western blot, this antibody detects an ~48kDa protein representing RbAp48 and a larger ~60kDa unknown protein from HeLa cell lysate.The PA1-869 immunogen is a synthetic peptide corresponding to residues M(1) A D K F A A F D D A V E E(14) C of human RbAp48. This sequence is completely conserved between human and mouse RbAp48. This immunizing peptide (Cat. # PEP-084) is available for use in neutralization and control experiments.
Specifications

Specifications

RbAp48
Polyclonal
Unconjugated
RBBP4
Liquid
RBBP4
Synthetic peptide corresponding to residues M(1) A D K F A A F D D A V E E(14) C of human RbAp48.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
Q09028
Retinoblastoma Associated Protein 48
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
5928
Documents
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