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MilliporeSigma™ anti-Reelin, aa 164-496 mreelin, Clone: G10, ™ (Chemicon™)
Supplier: MilliporeSigma™ MAB5364/DEL
Description
The highly layered structure of the cerebral cortex is established through the pattern of neuronal cell migrations. The first step is the creation of the primordial layer, the preplate, consisting of radial glial cells and the earliest generated neurons. Among these neurons are the Cajal-Retzius neurons. In the next step, the preplate splits into a superficial (marginal) zone, where the Cajal-Retzius neurons reside, and a deep subplate wherein the neurons form. Neurons migrating from the subplate form the cortical plate. This migration takes place on the radial glial fibers. The reeler mutant in mouse displays an abnormal pattern of cell migration throughout the cerebral and cerebellar cortices. The preplate forms normally, and the neurons differentiate at the correct times in the ventricular zone. However, instead of forming the normal inside-out arrangement of neurons in the cortical plate, the older neurons are found furthest from the ventricular zone, while the younger neurons do not migrate far at all. The reeler cerebral cortex is inverted from that of the wild type mouse.
Immunohistochemistry, Western Blotting
Specifications
Reelin, aa 164-496 mreelin | |
Unconjugated | |
Immunogen used was a recombinant fusion protein containing amino acid residues 164 - 496. | |
RUO | |
Primary | |
Semi-purified |
Monoclonal | |
Mouse | |
100 μg | |
Neuroscience | |
Human, Mouse, Rat | |
IgG1 |
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