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CD205 Mouse anti-Human, Clone: SPM487, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA138550

Catalog No. 01-672-796


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Description

Description

Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is normal kidney or renal cell carcinoma.

CD205 (LY25, Lymphocyte Antigen 75) is an integral membrane glycoprotein involved in antigen uptake, trafficking and presentation that improves the induction of antigen-specific T cell immunity. CD205 is highly expressed by CD8+ dendritic cells (DCs) and also expressed at different levels by bone marrow Gr1+ cells, Langerhans cells, (BMDC) bone marrow derived DCs and thymic epithelial cells. CD205 acts as an endocytic receptor that directs captured antigens to the extracellular space towards a specialized antigen processing region. Further, CD205 also prompts the reduced proliferation of B lymphocytes. Diseases associated with CD205 dysfunction include pneumonic plague and lipid pneumonia.
Specifications

Specifications

CD205
Monoclonal
0.27 mg/mL
PBS with 1% BSA and <0.1% sodium azide; pH 7.6
O60449
gp200
Mouse
IgG1, kappa
1 mL
4° C, do not freeze
Primary
4065
Immunohistochemistry (Paraffin)
SPM487
Unconjugated
LY75
Liquid
LY75
Recombit human gp200 protein.
Protein A/G
RUO
Antibody
Monoclonal
Human
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