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MilliporeSigma™ anti-Replication Protein A Clone: RPA34-19,

Mouse Monoclonal Antibody

Manufacturer:  MilliporeSigma™ NA18100UG

Catalog No. NA18100UG


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Description

Description

Specifically detects Replication Protein A Clone: RPA34-19 in Hamster, Human samples, and it is validated for Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation

The replication system of a cell contains several essential components among which are replication factor A (RFA, RPA, or HeLa cell SSB), PCNA, and replication factor C (RFC) as well as several other proteins. RPA, a multi-subunit protein containing a 70kDa, 34kDa, and 11kDa protein, may play a critical regulatory role in replication based on its functioning during both the initiation and elongation stages of DNA replication. The protein is highly conserved, having been identified in a range of species from yeast (Saccharomyces cerevisiae) to humans. The primary function of RPA appears to be as an auxiliary protein for both DNA polymerase α and δ. RPA undergoes a cell cycle dependent phosphorylation, which is restricted to the p34 protein. In addition to existing as part of the multi-subunit structure, p34 has also been identified as being present in a free, unphosphorylated form. Recent data shows that RPA is restricted to the nucleus and is overexpressed in transformed cells as well as in several tumor cells.
Specifications

Specifications

Replication Protein A
RPA34-19
In 50mM sodium phosphate buffer, 0.2% gelatin.
Murine
IgG2a
RUO
Primary
Recognizes the ∽34kDa unphosphorylaed and the complexed (phosphorylated) subunit of replication protein A in HeLa and U293 cells and breast carcinoma tissue.
Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
Unconjugated
Purified
replication protein A purified from U293 cells
100μg
2°C to 8°C
Monoclonal
Hamster, Human
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