RAR gamma-2 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA3814
Retinoic acid, a metabolite of vitamin A, is necessary for normal organogenesis but acts as a teratogen at high levels during embryonic and fetal development. Retinoic acid functions through its interaction with the nuclear protein, retinoic acid receptor (RAR). RAR belongs to the steroid and thyroid hormone superfamily of nuclear receptor proteins which exert their effects by binding to specific DNA response elements, thus regulating gene expression in target cells. RAR exists as three major subtypes: alpha, beta and gamma. Two main isoforms of RAR gamma exist: RAR gamma-1 has been found to be predominantly expressed in skin, while RAR gamma-2 has been found early in embryogenesis and in embryonal carcinoma cells. RAR gamma is also known as RARD.The corresponding gene for the retinoic acid receptor gamma 2 is NR1B3.PA3-814 detects recombinant human retinoic acid receptor (RAR) gamma 2. The immunizing sequence is 100% conserved in mouse. This antibody does not detect RAR gamma-1, or either of the alpha or beta forms of RAR.PA3-814 has been successfully used in WB, immunoprecipitation and gel shift procedures. In super shift assays this antibody incompletely shifts human RAR gamma-2/retinoid X receptor (RXR)/RAR response element complexes using various synthetic and natural RARE's.PA3-814 immunizing peptide corresponds to the N-terminus of RAR gamma-2. This antibody does not detect RAR gamma-1, or either of the alpha or beta forms of RAR. This peptide (Cat. # PEP-229) is available for use in neutralization and control experiments.
|whole serum diluted in PBS with 0.05% sodium azide|
|Gel Shift, Immunoprecipitation, Western Blot|
|Synthetic peptide corresponding to residues R(13) R L Y G A A G P G A G L L R R(28) of the N-terminal sequence of RAR gamma-2.|
|-20° C, Avoid Freeze/Thaw Cycles|
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