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RGS18 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141111

Catalog No. 01-675-697


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Description

Description

Suggested positive control: lung, spleen, or bone marrow lysates.

Regulators of G-protein signaling (RGSs) are a protein family that can act as GTPase-activating proteins for G(alphai)- and G(alphaq)-class proteins. One of these proteins, RGS18, isa 235 amino acid protein that is closely related to RGS5 (46% identity) and approximately 30-40% identity to other RGS proteins. This protein is expressed in platelet, leukocyte, and megakaryocyte cell lines. Engagement of TLR3 or TLR4 on monocyte-derived DCs potently down-regulates RGS18 and RGS14 without modifying other RGS proteins. A similar pattern of RGS protein expression occurrs in immature bone marrow-derived mouse DCs stimulated to mature via TLR4 signaling. The changes in RGS18 and RGS1 expression are likely important for DC function.
Specifications

Specifications

RGS18
Polyclonal
Unconjugated
RGS18
Liquid
RGS18
Synthetic peptide corresponding to residues 200-218 of human RGS18.
Protein G
RUO
Antibody
Polyclonal
Human
Western Blot
1.0 mg/mL
PBS with 0.05% sodium azide
Q9NS28
RP11-142L4.1, RGS13
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
64407
Documents
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