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RHAMM Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA521105

Catalog No. PIPA521105


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Description

Description

A suggested positive control is rat stomach tissue lysate. PA5-21105 can be used with blocking peptide PEP-1219.

The hyaluro-mediated motility receptor, also known as RHAMM, was initially identified as a soluble protein that could be released by sub-confluent migrating cells, promoting cell motility and invasion via interactions with hyaluro (HA) and the cell surface. While RHAMM is normally poorly expressed in most normal tissues and is not required for embryonic development or normal cell homeostasis functions, its expression is increased during wound repair in response to hypoxia and fibrogenic factors. However, its overexpression is transforming in multiple types of cancers and is required for maintaining RAS transformation. RHAMM associates with BRCA1 and BARD1, attenuating the mitotic-spindle-promoting activity of RHAMM, which may contribute to tumor progression by promoting genomic instability.
Specifications

Specifications

RHAMM
Polyclonal
Unconjugated
HMMR
Liquid
HMMR
An 18 amino acid peptide near the amino terminus of human RHAMM.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
O75330, Q00547, P97779
HMMR, CD168, IHABP, RHAMM, hyaluro mediated motility receptor, intracellular hyaluronic acid-binding protein, receptor for hyaluro-mediated motility
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
15366, 25460, 3161
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