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RhoGAP Rabbit anti-Bovine, Canine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141520

Catalog No. 01-675-342


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Description

Description

RhoGAP1 is a 439 aa intracellular GTPase activator for the Rho proteins (Rho, Rac and Cdc42).  It has a proline-rich domain, Src homology 3 (SH3) binding domain and three consensus box regions characteristic of RhoGAP. It stabilizes charges developing on the guanine nucleotide during the transition state for GTP hydrolysis and thus contributes to GAP-stimulated catalysis and converts the Rho proteins to their putatively inactive GDP-bound state with Cdc42 being the preferred substrate. Along with Rho proteins they modulate cytoskeletal changes and cell signaling. It is known to regulate the basal apoptosis of cells through the JNK pathway and also play a crucial role in regulating Rho-mediated signaling pathways. Recent reports suggest that this protein may also have a positive input to cell proliferation.
Specifications

Specifications

RhoGAP
Polyclonal
Unconjugated
ARHGAP1
Liquid
ARHGAP1
Human RhoGAP1.
Protein G
RUO
Antibody
Polyclonal
Bovine, Canine, Human, Mouse, Non-human primate, Rat
Western Blot
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
Q07960, Q5FWK3
CDC42GAP, RHOGAP, RHOGAP1, p50rhoGAP
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
228359, 311193, 392, 483631, 512817
Documents
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