RhoGAP Rabbit anti-Bovine, Canine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA141520
DescriptionRhoGAP1 is a 439 aa intracellular GTPase activator for the Rho proteins (Rho, Rac and Cdc42). It has a proline-rich domain, Src homology 3 (SH3) binding domain and three consensus box regions characteristic of RhoGAP. It stabilizes charges developing on the guanine nucleotide during the transition state for GTP hydrolysis and thus contributes to GAP-stimulated catalysis and converts the Rho proteins to their putatively inactive GDP-bound state with Cdc42 being the preferred substrate. Along with Rho proteins they modulate cytoskeletal changes and cell signaling. It is known to regulate the basal apoptosis of cells through the JNK pathway and also play a crucial role in regulating Rho-mediated signaling pathways. Recent reports suggest that this protein may also have a positive input to cell proliferation.
|Bovine, Canine, Human, Mouse, Non-human primate, Rat|
|PBS with 0.2% gelatin and 0.05% sodium azide|
|CDC42GAP, RHOGAP, RHOGAP1, p50rhoGAP|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|228359, 311193, 392, 483631, 512817|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok