Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Ricin alpha Mouse anti-Plant, Clone: RA999, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA174225

Catalog No. MA174225


Add to cart

Description

Description

MA1-74225 recognizes the alpha chain of ricin toxin RCA60.

Ricin toxin (RCA60), is a 60 kDa glycoprotein that consists of two chains, A and B, covalently linked by disulfide bond. The A chain acts as a glycosidase that removes an adenine residue from the 28S rRNA. The area from which the adenine is removed is essental for binding of elongation factors, destroying it leaves the ribosome inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, much faster than the cell can replace them, meaning that a single ricin A chain can kill a cell. The B chain binds to complex carbohydrates on the cell surface to facilitate entry of the A Chain into the cell. Without the B chain, the A chain has very low toxicity. Ricin is easily extracted from castor bean (Ricinus comunis), and the lethal dose for humans is very small. It is toxic when inhaled, ingested or injected and there is no known antidote, alhough a vaccine has been developed. Treatment is symptomatic and supportive, with long term organ damage likely in survivors. The ease of extraction and distribution makes it a potential candidate for bilogical warfare although it is less stable than other agents, such as anthrax.
Specifications

Specifications

Ricin alpha
Monoclonal
1 mg/mL
PBS with 0.09% sodium azide
P02879
LOC8287993
Full length Ricin A (RCA60) from Ricinus Communis.
Protein G
RUO
Antibody
Monoclonal
Plant
ELISA, Western Blot
RA999
Unconjugated
LOC8287993
Liquid
Mouse
IgG1
200 μg
4°C or -20°C if preferred
Primary
8287993
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit