RIG-I Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520276
A suggested positive control is C2C12 cell lysate.The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG-1) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG-1 activates the kinases TBK1 and IKK-iota through the adaptor protein IPS-1. These kinases then phosphorylate the transcription factors IRF-3 and IRF-7 which are essential for the expression of type-I interferons. RIG-1 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.
|human GST-tagged RIG-1 protein.|
|Human, Mouse, Rat|
|Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|RIG-I; DEAD box protein 58; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide; RIG-1; RNA helicase RIG-I; probable ATP-dependent RNA helicase DDX58; retinoic acid inducible gene I; retinoic acid-inducible gene 1 protein; retinoic acid-inducible gene I protein|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|230073, 23586, 297989|
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