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RIM2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520522

Catalog No. PIPA520522


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Description

Description

A suggested positive control is rat brain tissue lysate. PA5-20522 can be used with blocking peptide PEP-0642.

Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim 2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner. Rim2 is known to exist in multiple isoforms; this antibody should recognize most of them.
Specifications

Specifications

Rim2
Polyclonal
Unconjugated
RIMS2
Liquid
RIMS2
A 17 amino acid peptide near the center of the human Rim2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9UQ26, Q9EQZ7, Q9JIS1
OBOE, RAB3IP3, RIM2; RAB3 interacting protein 3; RIM 2; non-small cell lung cancer RimL3a protein; non-small cell lung cancer RimL3c protein; nuclear protein; rab-3-interacting molecule 2; rab-3-interacting protein 3; rab3-interacting molecule 2; regulating synaptic membrane exocytosis protein 2
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
116838, 116839, 9699
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