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RIP3 Rabbit anti-Human, Non-human primate, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141533

Catalog No. 01-675-353


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Description

Description

RIP3 is a novel member of RIP Ser/Thr kinase family. It is a potent inducer of apoptosis and is an important component of TNFR1 signaling complex. RIP3 consists of an N-terminal RIP-like-Kinase domain and a unique, non-homologous C-terminus responsible for caspase activation and apoptosis induction. RIP3 is expressed in multiple tissues including hematopoietic cells and plays a functional role in the regulation of apoptosis and NF-kB signaling. It is recruited to the TNFR1 signaling complex in a RIP-dependant manner where it induces apoptosis by activating caspases and/or inhibiting TNFR1-induced NF-kB activation. RIP3 negatively regulates the TLR3-Trif-mediated NF-kB signaling pathway by competing with the binding of Trif to RIP1. The human RIP3 gene is localized in the chromosomal region 14q11.2.
Specifications

Specifications

RIP3
Polyclonal
Unconjugated
RIPK3
Liquid
RIPK3
Synthetic peptide corresponding to residues 497-510 and 298-311 of human RIP3.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Non-human Primate
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 0.05% sodium azide
Q9Y572
RIP3
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
11035
Documents
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