MilliporeSigma™ anti-RNA Polymerase II, Clone: CTD4H8, ™ (Upstate™)

Supplier:  MilliporeSigma™ 05623/DEL

Catalog No. 50-171-729

Description

RNA polymerase II (Pol II) is a multi-subunit enzyme responsible for the transcription of protein-coding genes. Transcription initiation requires recruitment of the complete transcription machinery to a promoter via solicitation by activators and chromatin remodeling factors. Pol II can coordinate 10 to 14 subunits. This complex interacts with the promoter regions of genes and a variety of elements and transcription factors. The DNA binding domain of the polymerase is a groove where TFIIB orients the DNA for unwinding and transcription. GenBank Number: NM_000937. MW: 210-220kDa.

Chromatin Immunoprecipitation, Western Blotting

Specifications

• Antigen: RNA Polymerase II
• Conjugate: Unconjugated
• Immunogen: Peptide containing 10 repeats of YSPT[pS]PS corresponding to the carboxyl-terminal domain of RNA polymerase II
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Semi-purified

• Classification: Monoclonal
• Host Species: Mouse
• Quantity: 200 μg
• Research Discipline: Epigenetics
• Target Species: Human, Mouse, Rat, Yeast
• Isotype: IgG1