RNF168 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520738
A suggested positive control is human brain tissue lysate. PA5-20738 can be used with blocking peptide PEP-0852.RNF168 was identified as a chromatin-associated RING finger protein that acts as a ubiquitin ligase both in vitro and in vivo. RNF168 targets histones H2A and H2AX, but not H2B, forming K63 polyubiquitin chains. Upon formation of DNA double strand breaks, RNF168 is recruited to the site of DNA damage where it co-localizes with -gammaH2AX and 53BP1 in an RNF8-dependent manner. This localization of RNF168 increases the local concentration of ubiquinated proteins to the threshold required for retention of the proteins 53BP1 and BRCA1, facilitating the downstream signaling cascade. Thus, RNF168 defines a new pathway demonstrating a functional cooperation between E3 ligases in genome maintece. At least three isoforms of RNF168 are known to exist.
|An 18 amino acid peptide from near the carboxy terminus of human RNF168.|
|Antigen affinity chromatography|
|PBS with 0.02% sodium azide|
|E3 ubiquitin-protein ligase RNF168|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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