RNF8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520961
A suggested positive control is human lung tissue lysate. PA5-20961 can be used with blocking peptide PEP-1075.RNF8 was identified as a ubiquitin ligase (E3) containing a RING finger motif and a FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes including UBE2E1/UBCH6, UBE2E2, and UBE2E3. RNF8 assembles at DNA double-strand breaks (DSBs) via interactions though the FHA domain with the adaptor protein MDC1, resulting in an increase in DSB-associated H2A histone ubiquitinations mediated by the associated ubiquitin ligase RNF168 followed by the accumulation of 53BP1 and BRCA1 repair proteins. Together with RNF168, RNF8 plays an integral part of class switch recombination in B cells, allowing the production of several classes of antibodies, through the recruitment of 53BP1 and BRCA1 to the DSB sites.
|A 14 amino acid peptide near the carboxy terminus of human RNF8.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|O76064, Q8VC56, Q4KLN8|
|C3HC4-type zinc finger protein; E3 ubiquitin-protein ligase RNF8; UBC13/UEV-interacting ring finger protein; ring finger protein (C3HC4 type) 8|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|361815, 58230, 9025|
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