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ROCK-I Mouse, Unlabeled, Clone: 46, BD

Mouse Monoclonal Antibody

$225.00 - $445.00

Specifications

Antigen ROCK-I
Isotype IgG1
Immunogen Mouse ROCK-I aa. 906-1012
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611137
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BD Biosciences
611137
150μg Each for $445.00
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BDB611136
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BD Biosciences
611136
50μg Each for $225.00
Add to cart
 
Description

Description

ROCK-I is a Rho-associated serine/threonine kinase isozyme that mediates RhoA-induced assembly of focal adhesions and actin stress fibers. It contains an N-terminal kinase domain, a central 600 amino acid long coiled-coil region, a C-terminal pleckstrin homology region (PH) and a Cys-rich zinc finger motif. The ROCK-I kinase domain is approximately 90% identical to that of ROCK-II. ROCK-I binds GTP-bound Rho through a Rho-binding domain (RBD). As a result, the kinase activity of ROCK-I is moderately stimulated. The ROCK isozymes regulate cell contractility through phosphorylation of the myosin light chain. This effect results from either the inhibition of the myosin phosphatase or by direct phosphorylation of the myosin light chain, thus bypassing the myosin light chain kinase. In addition, ROCK-I activates the ubiquitously expressed Na-H exchanger (NHE1) via a number of mechanisms including RhoA. NHE1 may mediate ROCK-I-induced changes in the actin cytoskeleton. Therefore, ROCK-I plays an important role in the regulation of focal adhesion and stress fiber formation.

Host Species: Mouse
Clone: 46
Isotype: IgG1
Species Reactivity: Mouse
Immunogen: Mouse ROCK-I aa. 906-1012
Formula Weight [Chemical]: 160kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

ROCK-I
Mouse ROCK-I aa. 906-1012
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
ROKβ
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
46
250μg/mL
Store undiluted at -20°C.

For Research Use Only.

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