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ROR gamma Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA132610

Catalog No. PA132610


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Description

Description

PA1-32610 detects ROR gamma from human samples. PA1-32610 has been successfully used in immunohistochemistry (paraffin tissue) applications. The PA1-32610 immunogen is a synthetic peptide, KLH conjugated. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.

ROR gamma, a NR1 Thyroid Hormone-Like receptor, has been shown to affect thymopoiesis, bone metabolism, T-cell apoptosis, and lymphoid organogenesis. ROR gamma has been shown to promote thymocyte survival by activating the expression of the antiapoptotic protein Bcl-x(L). ROR gamma is also required for the development of lymph nodes and Peyer ft.s patches. It has been shown that ROR gamma t, a thymus-specific isoform of ROR gamma from mouse, inhibits Fas ligand expression and cytokine secretion in immature thymocytes. ROR gamma binds as a monomer to response elements composed of a single core motif, GGTCA, preceded by a 6 bp AT-rich sequence. ROR gamma expression has been documented in mouse thymus, adipose, bone, skeletal muscle, liver, and kidney, and in human skeletal muscle. ESTs have been isolated from human tissue libraries, including cancerous head/neck, germ cell, and prostate, and normal colon, head/neck, lung, liver/spleen, and pancreas.
Specifications

Specifications

ROR gamma
Polyclonal
Unconjugated
RORC
Liquid
RORC
Synthetic peptide, KLH conjugated.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin)
1 mg/mL
PBS with 0.01% sodium azide; pH 7.7
P51449
MGC129539, NR1F3, RORG, RZR-GAMMA, RZRG, TOR
Rabbit
IgG
25 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
6097
Documents
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