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RORgammat Mouse anti-Human, Brilliant Violet 650, Clone: Q21-559, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 563424

Catalog No. BDB563424


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Description

Description

The Q21-559 monoclonal antibody recognizes ROR gamma t (RORγt), an isoform of RORgamma (RORγ). RORγt is a DNA-binding transcription factor that is encoded by the RORC (RAR-related orphan receptor C) gene. It belongs to the ROR/RZR orphan nuclear receptor family. Two protein isoforms are produced from the RORC gene by alternative splicing: RORγγt is highly restricted to the thymus where it is expressed exclusively in immature CD4+CD8+ thymocytes and in peripheral Th17 and LTi cells. RORγt reportedly functions as an essential transcription factor for the development of secondary lymphoid tissues. It also plays an important regulatory role in thymopoiesis and effector T cell differentiation, especially for Th17 cells.

Specifications

Specifications

RORgammat
Q21-559
RORgt; ROR gamma t; RORC; NR1F3; RORG; RZRG; TOR; RZR-GAMMA
Affinity Purified
Human RORgammat Recombinant Protein
50 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
Brilliant Violet 650
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Murine
IgG2b, κ
RUO
Primary
Human
Documents
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