RRM1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527263
PA5-27263 targets RRM1 in IHC (P) and WB applications and shows reactivity with Human and mouse samples. The PA5-27263 immunogen is recombit fragment corresponding to a region within amino acids 246 and 792 of Human RRM1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in maligcies and disease that involve this region.
|Recombit fragment corresponding to a region within amino acids 246 and 792 of Human RRM1|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7|
|R1, RIR1, RR1, ribonucleoside-diphosphate reductase large subunit, ribonucleoside-diphosphate reductase subunit M1, ribonucleotide reductase M1 polypeptide, ribonucleotide reductase, R1 subunit, ribonucleotide reductase, large subunit|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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