DDIT4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520495
A suggested positive control is human kidney tissue lysate. PA5-20495 can be used with blocking peptide PEP-0615.RTP801 was initially identified as a gene induced by DNA damage, and later found to also be regulated by other cellular stresses such as hypoxia and glucocorticoid treatment. Recently, RTP801 has been shown to act as a mediator of tuberous sclerosis complex (TSC)-dependent regulation of the mammalian Target of Rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle. In response to energy stress, RTP801 inhibits mTOR function, resulting in dephosphorylation of downstream targets such as ribosomal protein S6 kinase 1 and 4EBP1 and decreasing cell growth. Disregulation of RTP801 may thus contribute to human tumorigenesis.
|a 12 amino acid peptide from near the center of human RTP801.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|Q9D3F7, Q8VHZ9, Q9NX09|
|Dig2, REDD-1, REDD1, RP11-442H21.1, RTP801; DNA damage-inducible transcript 4 protein; HIF-1 responsive RTP801 (RTP801); HIF-1 responsive protein RTP801; protein regulated in development and DNA damage response 1|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|140942, 54541, 74747|
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