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S100, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA128230

Catalog No. PIPA128230

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. S100 protein may function in stimulation of Ca2+ induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. Immunoreactive S100 protein localizes in the cytoplasm and nuclei of astrocytes, Schwann's cells, ependymomas and astrogliomas. Ganglion cells do not stain for S100 protein. S100 can be detected in almost all benign naevi and malignant melanocytic tumours of the skin, and in Langerhans cells in the skin.

PA1-28230 detects S100 from human samples.PA1-28230 has been successfully used in immunohistochemistry (paraffin tissue) applications.The PA1-28230 immunogen is Recombinant protein encoding human S100 protein.
Specifications

Specifications

S100
Polyclonal
PBS with 1% BSA and 0.1% sodium azide; pH 7.4
P23297
Bpb, NEF, S 100
Rabbit
IgG
7mL
Store at 4°C
Primary
6271
Immunohistochemistry (Paraffin)
Unconjugated
S100A1
Purified
S100A1
Recombinant protein encoding human S100 protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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