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S100A12 Mouse anti-Human, Clone: 161205, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523925

Catalog No. PIMA523925


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Description

Description

This antibody detects recombit human EN-RAGE in direct ELISAs. Reconstitute at 0.5 mg/mL in sterile PBS.

S100A12 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A12 is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. S100A12 is also a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B, a key transcription factor for inflammatory events, is activated by S100A12/RAGE. S100A12 has also been shown to have anti-microbial properties.
Specifications

Specifications

S100A12
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P80511
CAAF1, CAGC, calcium binding protein in amniotic fluid, calgranulin C
Mouse
IgG2B
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
6283
Flow Cytometry, Western Blot
161205
Unconjugated
S100A12
Lyophilized
S100A12
E. coli-derived recombit human EN-RAGE Met1-Glu92
Protein A/G
RUO
Antibody
Monoclonal
Human
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