Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

S100B Mouse, Unlabeled, Clone: 19, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 612376

Catalog No. BDB612376


Add to cart

Description

Description

The S100 multigene family consists of a number of small dimeric molecules around 100 residues in length. The original members of this family, S100A and S100B, were initially identified in bovine brain. Other S100 proteins have also been identified, such as S100P from human placenta and S100L from bovine lung. The S100 family consists of at least 10 members which show a cell-type-specific expression pattern. Most S100 proteins are believed to be involved in Ca2+; signaling pathways. S100P consists of 95 amino acids and shares about 50% sequence identity with S100A and S100B, while S100L has been shown to possess 43-47% homology to S100A and S100B. S100B is expressed in the nervous system by glial cells, such as astrocyte, oligodendroglial, ependymal, and microglial cells. The dimeric form of S100B has been implicated in neuronal survival, neurite extension, and astrocyte growth. In addition, S100B expression is induced by stimulations that activate p53, and S100B activity may be involved in PKC-dependent p53 nuclear translocation in early G1 phase. Thus, S100B plays a role in calcium signaling pathways that regulate cell differentiation and cell cycle progression.

Immunofluorescence, Western Blotting

Specifications

Specifications

S100B
19
Unconjugated
Affinity Purified
Mouse S100B aa. 1-92
50μg
Cell Biology
Primary
Human, Murine, Rat
In vitro Assay, Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit