SLC39A3 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA526215
DescriptionThe zinc transporter ZIP3, also known as SLC39A3, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. Similar to knock-outs of ZIP1 and ZIP2, ZIP3-null mice have no phenotypic differences compared to wild-type mice. Only when ZIP1, ZIP2, and ZIP3 genes are all eliminated and these mutant mice are fed a zinc-deficient diet do abnormalities such as reduced embryonic-membrane bound alkaline phosphatase activity and abnormal development occur, indicating that the ZIP1-3 proteins play an important, noncompensatory role when zinc is deficient. More recent studies have shown that ZIP2 and ZIP3 are down regulated in human prostate adenocarcinomatous glands, and may be important in the retention of zinc in the cellular compartment.
|PBS with 0.09% sodium azide|
|ZIP3, ZIP-3, solute carrier family 39 member 3, zinc transporter ZIP3, zrt- and Irt-like protein 3|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry, Western Blot|
|KLH conjugated synthetic peptide between 106-134 amino acids from the central region of human S39A3|
|Antigen affinity chromatography|
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