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p70 S6 Kinase Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA512722

Catalog No. PIPA512722

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This antibody is predicted to react with bovine, mouse, rat and rabbit based on sequence homology.

The p70 S6 kinase (p70 Ribosomal Protein S6 Kinase, p70S6K) is a 70 kDa member of the ribosomal S6 kinase (RSK) family of serine/threonine kinases. p70 S6 kinase is predomitly localized in the cytoplasm, and is essential in growth factors regulated cell proliferation, pathways involving cell motility, such as metastases, the immune response, and tissue repair. p70 S6 kinase acts downstream of phosphoinositide (PI) 3-kinase, and its main physiological target is the S6 ribosomal protein, which is involved in upregulation of protein synthesis. The kinase activity of p70 S6 kinase leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding p70 S6 kinase and overexpression are seen in some breast cancer cell lines.
Specifications

Specifications

p70 S6 Kinase
Polyclonal
PBS with 0.09% sodium azide
P23443
Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase I; S6K; S6K1; 70 kDa ribosomal protein S6 kinase 1; p70 S6 kinase alpha; p70(S6K)-alpha; p70-S6K; P70S6K; p70-alpha; RPS6KB1; STK14A;
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
6198
Immunohistochemistry, Western Blot
Unconjugated
RPS6KB1
Liquid
RPS6KB1
KLH conjugated synthetic peptide between 277-306 amino acids from the central region of human S6K (RPS6KB1)
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
Documents
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